BioPharmaceutical Process - doverpac

BioPharmaceutical Process

Contained Buffer and Media Prep Powder Addition with our Powder Transfer Bag

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DoverPac® with Restraint

DoverPac® without restraint

DoverPac® SF on weigh
scale at FAT

Drum Transfer Liners


DoverPac® SF with Rinse Tube
ILC Dover supports the BioPharmaceutical Industry with cGMP processing for Buffer and Media prep. In order to make the move to closed processing at these steps in the process train, two distinct solutions have been implemented at various international manufacturers. These include the DoverPac® SF and the Conical Drum Transfer Sleeve.

Proven Market driven needs that these products support include:

  • Packaged to weight after receipt of raw materials
  • Speed to Market
  • Value added with reduced Capital Costs
  • Customizable to specific process needs
  • Gravity feed and highly drainable
  • Scale up


Benefits that have been seen include:

  • Proven reliability
  • Closed processing
  • Smaller foot print
  • cGMP applications
  • Materials of contact at stringent levels met with the ArmorFlex® film
  • Click here to download DoverPac® SF Powder Transfer Systems (pdf)
  • Click here to view webinar BioPharm Applications and Capabilities Video


DoverPac® SF

The DoverPac® SF consists of a series of standard and customized applications. This expansion of single-use manufacturing is designed to be attached to a variety of process vessels with an integral sanitary flange. Filling the liner and charging the vessel are done using the same flange interface.
These are supplied either with or without a removable restraint and use a lifting bar and standard hoist to position this transfer device over the vessel.
Over 99.5% dry powder transfer has been seen. Key in this feature is the blended heat seal seam that is made at the interface of the liner and the flange. An option exists to include a rinse tube to flush the liner should that be desired.
 
A version with an open top for filling and a bottom neck with a sanitary flange for attachment to the vessel has also been used in manufacturing. This style includes integral film lifting loops on the liner to support hoisting the filled pack without a fabric outer restraint. This was done to meet the non-shedding requirements for that customer's specific process area requirement.
 
Click here to download Disposable Process Solutions Guide (pdf)
 
Current volumes and Sanitary Flange attachment sizes include:
 
 

Drum Transfer Liners

Another proven method for cGMP processing is also available now using drums, a conical drum funnel and drum lifts.
What makes this a viable approach is the use of ILC's disposable Conical Transfer Sleeve. This system interfaces with standard process equipment and vessels to achieve a clean transfer of a variety of powders.
 
The liner is attached to the drum after removal of the lid and opening the inner drum liner. The stainless steel cone on the lifter is then positioned over the drum and the liner is pulled through the cone and held in position with a clamp on the cone. After inverting the drum, the Drum Transfer Liner is attached to the vessel nozzle. The clamp can then be opened allowing gravity feed of the powder into the vessel for processing.
 


DoverPac® SF on weigh scale at FAT


DoverPac® SF with rinse tube
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